In terms of comfort, the G600 is ideal for those who prefer a palm grip. There is no thumb groove because the thumb controls 12 of the 20 buttons. Rather, the index finger is in charge of the left button, the middle finger is in charge of the right button, and the ring finger is in charge of a third button that activates the mouse’s macro controls. The G600 is a bit heavier than the average gaming mouse, weighing 4.69 ounces (133 grams), and measuring 4.6 x 2.9 x 1.6 inches (118 x 75 x 41 mm). The heft, on the other hand, makes the mouse feel substantial and satisfying to use. Those who prefer claw or fingertip grips should be aware that this is not the mouse for them. Logitech made the mouse tall to accommodate the 12 thumb buttons, so you have to stretch your fingers across it. Claw users’ grips will be inefficient, and fingertip users will be unable to click the left button at all. The mouse’s main selling point is its thumb buttons, but what they offer in versatility, they lack in distinctness. Each button has a slightly different feel, but not sufficiently so. Learning to navigate between 12 buttons with only one digit takes time, and doing so when the buttons only differ through very subtle contours means you’ll make a lot of mistakes at first. Overall, the G600 is a comfortable mouse, but its main selling point is its plethora of buttons, which takes some getting used to and could have been easier to use. The mouse is also only available in right-handed mode, so left-handed users are out of luck. The G600’s software, like its thumb buttons, is a mixed bag. The software is extremely deep and customizable, but only the most patient users will be able to take advantage of everything it has to offer. The G600 has six profiles available: three in the mouse and three on the computer. Eighteen of its twenty buttons are programmable, with the remaining two being the standard left and right mouse buttons. Unfortunately, users cannot freely switch between all six profiles. When you launch the Logitech G600 software, you’ll be asked whether you want to use the mouse profiles or the computer profiles. It’s simple to adjust between games, but it’s practically impossible to do so while playing.